LEPTOSPIROSIS COMPLICATIONS, CAUSES OF DEATH AND PATHOMORPHOGENESIS
DOI:
https://doi.org/10.51699/mjssh.v1i5.326Keywords:
leptospirosis, disease course, diagnosis, treatment, preventionAbstract
Leptospirosis is a natural focal zoonosis that is widespread in the European territory of the Uzbekistan, characterized by a severe course and prolonged convalescence [1-3]. The disease is registered with different intensity in all districts of Russia (Figure 1), so in 2012 leptospirosis was observed in 37 administrative territories [4-6]. The highest incidence is observed in 2) [1, 7]. The active natural focus of leptospirosis in the Kuban region supports the incidence with periodic increases every 3-4 years (0.61–12.0 cases per 100 thousand populations). Since 2018, the incidence rate has decreased to 0.6-0.8 cases per 100 thousand populations, while sporadic cases with a severe complicated course with a mortality rate of up to 15% remain. Improved diagnosis and organization of medical care, and the introduction of new treatment regimens for leptospirosis significantly reduced mortality [8-12]. At the same time, the structure of fatal outcomes has changed, both in terms of the time of onset and the nature of the complications that determine them. Multiple organ failure syndrome and septic complications associated with the activation of endogenous infection or the addition of secondary complications against the background of immunodeficiency developing in severe leptospirosis began to come to the fore among life-threatening conditions [2, 13, and 14].
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