INSULIN-LIKE GROWTH FACTOR AND HYPERTENSION
DOI:
https://doi.org/10.51699/mjssh.v1i5.375Keywords:
diabetes mellitus, prevention, diagnosis, treatmentAbstract
Insulin-like growth factor-1 (IGF-1) polypeptide is a representative of growth factors and is close to insulin by its physiological effects. This factor plays an important role in the mechanisms of regulation of the structure and function of the myocardium and blood vessels. IGF-1 is detected in the processes of hypertrophy of the heart and blood vessels. A number of authors link IGF-1 to prognostic biological signs of the development of heart failure.
To date, the pathogenetic role of IGF-1 in the development of injuries of the cardiovascular system, including arterial hypertension, type 2 diabetes and their combination, remains unclear. In this regard, it is of great scientific interest to determine the relationship between the level of IGF-1 in the blood and the structural and functional parameters of the heart and carotid artery in patients with type 2 diabetes, hypertension. Treatment with metformin in patients with hypertension with type 2 diabetes resulted in a significant decrease in IGF-1 levels in the blood. This was particularly evident in patients with concentric left ventricular hypertrophy prior to treatment and with elevated IGF-1 levels. However, the addition of long-acting glyclazide to metformin, no decrease in IGF-1 levels in the blood of patients after treatment was not observed [1].
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